Otto-von-Guericke-Universität Magdeburg

University Department of Neurology
 
 
 
 
 
 
 
 
 
 
 
 
botox
 

Botulinum Toxin Therapy

Head

Senior Physician Imke Galazky

Topic

What is botulinum toxin and how does it work?

Botulinum toxin is a neurotoxic protein occurring worldwide produced by the anaerobic bacterium Cloareisium botulinum. If this bacterium occurs in food, it can cause botulism, a life-threatening food poisoning.

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Duration of Effectiveness

The effect of botulinum toxin begins within a few days (depending on the dose and size of the muscles) and averages 3 to 4 months (with individual variations). After this period, further injection is required, with the dose to be adjusted depending on the effectiveness of the preceding injection. This therapy, is, therefore, not a cure, but serves to alleviate symptoms, which will occur again as the drug’s effectiveness weakens. Any unintended side effect of the treatment will also weaken and then vanish completely. Consequently, botulinum toxin can provide a long-lasting, problem-free treatment that can, if required, be continued for decades.

Contraindication

Therapy may not take place when illnesses of neuromuscular transmission (Myasthenia, Lambert-Eaton syndrome) are present, during pregnancy and lactation, in hemophiliacs taking anticoagulants (Marcumar, Falithrom), or when there are severe infections or severe myopathies in the area of the injection.

Treatment Prioities in our Outpatient Clinic

Focal Dystonia

Dystonias are sustained, involuntary muscle contractions, which through a malfunctioning interaction of the musculature frequently cause bizarre twisting and repetitive movements or abnormal postures.

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Hemifacial Spasm (half-sided face spasm)

This is causued by a peripheral damage of the facial motor nucleus and/or central areas.  Treatment with botulinum toxin may be indicated by this condition.

Spastic Movement Disorder

Spasticity is a neurogenically related muscular hyperactivity which is produced by a central injury to the descending motor pathways (for example, apoplexy)  Clinical symptoms are increased muscle tone, spastic paralysis, and impaired muscle coordination.

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Clinical Trials

In addition to the diagnosis and treatment of dystonias and the treatment of spasticity with botulinum toxin, the botulinum treatment program seems to advance scientific knowledge. For this reason, we participate in studies concerned with the quality of life in patients undergoing chronic botulinum toxin treatment,and the tolerability of botulinum toxin in these patients. We also participate in studies of the tolerability and effi cacy of newly developed

botulinum toxin preparations, and the use of botulinim toxin for„off -label“ indications (those not as yet recognized for treatment with botulinum toxin).

The formation of Spasticity Competence Center in collaboration with the Magdeburg Neurological Treatment Center is in the planning stages.

Contact

Otto-von-Guericke University
University Department of Neurology
And University Department of Stereotactic Neurosurgery
University Medical Center Magdeburg A.ö.R
Leipziger Str. 44
39120 Magdeburg,
Germany

Phone:  +49 0391 6713484

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Last Modification: 25.01.2017 - Contact Person: Ögelin Düzel
 
 
 
 
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