UNIVERSITY DEPARTMENT OF NEUROLOGY

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Dementia/Cognitive Disorders

Head

Wenzel Glanz (Specialist in Neurology, DZNE Magdeburg)

Dr. Daniel Bittner (Specialist in Neurology, University Clinic for Neurology)

 

Staff


Urte Schneider (Case Manager)
Christin Russ (MTA)
Franziska Schulze (MTA)
Deike Hartmann (MTA)
Anika Weber (MTA)
Sabrina Rädler (Assistant)

Collaborations

  • Prof. Anita Hökelmann, Institute of Sport Science, Magdeburg
  • PD Dr. Dr. Bernhard Baier, University Clinic for Neurology,Mainz
  • Prof. Agnes Flöel, University Clinic for Neurology, Charité, Berlin
  • Prof. Thomas Münte, University Clinic for Neurology, Lübeck
  • Dr. Silke Klose, Prof. Peter Mertens,University Clinic for Nephrology and Hypertension, Diabetology and Endocrinology, Magdeburg
  • Prof. Volkmar Leßmann, Prof. Tanja Brigadski, Institute of Physiology, University Magdeburg
  • Prof. Rüdiger Braun-Dullaeus, University Clinic for Kardiology, Magdeburg
  • Prof. Jens Schreiber, University Clinic for Pneumology, Magdeburg
  • Prof. Reinhard Dengler, University Clinic for Neurology, MH-Hannover

Offers of the memory clinic

The memory clinic is part of the “Cooperation Unit for Applied Prevention Research” (KAP). This latter unit is jointly operated by the University Clinic and the German Center for Neurodegenerative Diseases (DZNE, for more information see the Research Section). Persons who have the feeling that their cognitive abilities, especially memory, are deteriorating (or are told so by others) can ask for an appointment in the memory clinic. When a patient presents in the clinic for the first time, our primary goal is to clarify whether the subjectively experienced deficits could really point to a beginning dementia syndrome or instead reflect a normal age-related decline.

How can one determine whether increasing forgetfulness is a sign of beginning dementia?

Patients who present themselves in our clinic for the first time – either on their own request or at the recommendation of others (family members, GP) – will be asked to fill in questionnaires regarding their past and present medical history, regularly taken drugs etc.

Thereafter, an extensive neuropsychological test battery will be administered to measure cognitive functions like orientation, attention, speech and executive functions. In the subsequent consultation an experienced neurologist will explain the test results and their consequences. Often enough patients can be calmed down as their performance is within the normal age range and no signs for dementia are found. Nevertheless, every patient is invited for further consultations in the future because sometimes even a mere subjective impairment involves a (slightly) increased risk of later dementia. In case the reported symptoms and test results are not within the normal range we recommend a further diagnostic workup preferentially performed during a 3-day stay in our Clinic for Neurology. During this stay the necessary additional tests can be administered effectively and at a high technical level.
The following additional tests will then be performed, whereby other investigations may be necessary in an individual case:

  • High-resolution 3 T magnetic resonance tomography of the brain.
    Is there evidence for pathological brain atrophy, for vascular disease or for other pathologies that may cause cognitive decline?
  • Extended neuropsychological assessment.
    Experienced neuropsychologists will complement and evaluate the cognitive tests. With this extra testing a more exact classification of the deficits and their affiliation to specific forms of dementia can be achieved.
  • Analysis of the CSF regarding biomarkers.
    Biomarkers are proteins that are produced during the course of AD; evidence of these biomarkers therefore can support the diagnosis of AD.
  • Blood tests.
    Blood will be screened for pathologic findings that also may impair cognitive functions but are not related to dementia, for example thyroid dysfunction or lack of vitamins.
  • Measuring of brain waves with EEG and of brain blood oxygenation with NIRS.
    These methods can help to distinguish between pseudodementia related to depression and (real) neurodegenerative dementia.
  • Ultrasound testing of brain feeding arteries.
    Is there evidence for stenosis hindering blood flow to the brain?

 

Further offers of the memory clinic

  • Continuous medical consultation.
    Experienced neurologists take care of the patients and prescribe drugs intended to stabilize memory functions and, if necessary, drugs aimed at reducing challenging behavior.
  • Caregiver counseling.
    We offer group meetings for caregivers in which advice regarding how to deal with the patient’s behavior will be given. This offer also aims at reducing the caregiver’s burden.
  • Social counseling.
    We give information regarding possible support offered by health insurances und charity.
  • Counseling regarding home arrangement.
    We offer advice regarding how to design and organize the patient’s home in order to allow an independent living.
  • Prevention and intervention programs./strong>Within the KAP we regularly offer training programs aimed at supporting cognitive functions and quality of life in the elderly. In most cases these programs involve a combination of physical and mental exercise.

The memory clinic is open to all persons who have worries regarding their mental capabilities. No letter of referral is required. For arranging an appointment call: 0391-6724555.

Collaborations

  • Dr. Barbara Romero, SET-Institute, Berlin
  • Christel Dost, Vitanas Dementia Center Am Schleinufer, Magdeburg
  • PD Dr. Kolja Schiltz, University Hospital for Psychiatry, Magdeburg
  • Prof. Dan Rujescu, University Hospital for Psychiatry, Halle
  • Prof. Agnes Flöel, Department of Neurology, Charité University Hospital, Berlin

Dementia and prevention research

Since the foundation of the DZNE in 2008 research regarding neurodegenerative diseases and dementia is a new focus within the already strong neuroscientific community in Magdeburg. The different research groups of the DZNE (for more information see www.dzne.de) intensively cooperate with the University Clinic. In this respect, the recently founded cooperation unit for applied prevention research (KAP) that is jointly operated by the two institutions should be highlighted.

The KAP – who we are

The KAP is meant to constitute an interface between basic research and clinical application. Findings from the DZNE’s basic research departments regarding non-pharmacological interventions will be adopted to develop training programs for the elderly.

Here is an example: it is known from animal research that physical exercise together with sensory enrichment induces neurogenesis in certain regions of the brain even in adult animals. Within the KAP we strive to adopt these interventions for the needs of older humans and to test whether effects similar to the adult neurogenesis observed in the animal model can be achieved. The following prevention and intervention programs have been or are currently applied:

  • Dancing (in cooperation with the Institute for Sports Sciences).
    Dancing combines physical exercise with continuous learning of new movement sequences, navigation in space and social interaction. We think that this combination is especially effective in strengthening the brain and in reducing the detrimental influence of dementia.
  • Sensorimotor coordination training.
    We believe that this sort of training is also suitable to challenge different brain regions. Moreover, this training also improves balance and avoids falls, factors which are important to guarantee mobility in daily life.
  • Feedback based training of executive functions (in cooperation with Prof. Münte, Lübeck).
    In this program functions that are important for planning behavior (i.e. how to get from A to B) will be trained intensively. These functions may be more important for self-dependence in daily life than intact memory.
  • Training of attentional selection.
    It is known, that persons who effectively filter out irrelevant information have a higher memory capacity. Here we ask whether training of these filter abilities can be used to increase memory performance.
  • Electric brain stimulation.
    By applying a weak and pain free electric current on the scalp we hope to be able to improve certain cognitive functions.
  • Napping (in combination with electric brain stimulation).
    Does napping (short daytime sleep), supported by electric brain stimulation, improve memory?
  • Navigation training (in cooperation with Prof. Wolbers, DZNE).This trainings aims at improving orientation capabilities in the elderly. Disrupted orientation skills hinder one from leaving home and thus increase social isolation.

 

Contact

Head:
Wenzel Glanz (Specialist in Neurology, DZNE Magdeburg)

Deputy Head:
Dr. Daniel Bittner (Consultant Neurologist)

Otto-von-Guericke University
University Department of Neurology
And University Department of Stereotactic Neurosurgery
University Medical Center Magdeburg A.ö.R
Leipziger Str. 44
39120 Magdeburg, Germany

Phone:  +49 (0391) 67-24555
Fax:  +49 (0391) 67-24527

Selected References

Maass A, Duzel S, Gorke M, Becke A, Sobieray U, Lovden M, Lindenberger U, Backman L, Braun-Dullaeus R, Ahrens D, Heinze H, Muller N, & Duzel E (2014) Vascular hippocampal plasticity after aerobic exercise in older adults. Molecular Psychiatry

Zaehle T, Becke A, Naue N, Machts J, Abdulla S, Petri S, Kollewe K, Dengler R, Heinze HJ, Vielhaber S, Müller NG. (2013) Working memory in ALS patients: preserved performance but marked changes in underlying neuronal networks. PLoS One. 2013 Aug 8;8(8).

Heimrath K, Sandmann P, Becke A, Müller NG, Zaehle T. (2012) Behavioral and electrophysiological effects of transcranial direct current stimulation of the parietal cortex in a visuo-spatial working memory task. Front Psychiatry. 20;3:56.

 

Last Modification: 01.10.2018 - Contact Person:

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