UNIVERSITY DEPARTMENT OF NEUROLOGY

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Neuromuscular Disorders

Head

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Prof. Dr. med. Stefan Vielhaber (Spokesperson)
Prof. Dr. med. Helmut Feistner (Director)
Prof. Dr. med. Christian Mawrin (Deputy Director)

Staff

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Dr. med. Susanne Abdulla (Rotation Assistant)
Dr. med. Ute Bock (Senior Neurologist, MVZ)
Dr. Heike Stephanik (Neurologist)
PD Dr. med. Stefanie Schreiber (Neurologist)

Clinical Psychology

 
Judith Wesenberg, M. Sc.
Frau M. Veit, B. Sc.

Outpatient Clinic


Christa Sobetzko (Secretary)
Schw. Heike Knape (Nurse)
Schw. Andrea Goedecke (Nurse)

The Muscle Center: An Overview

In the Magdeburg Neuromuscular Center patients with neuromuscular diseases are cared for by an interdisciplinary team of cooperating neurologists, heart and lung specialists, geneticists, orthopedists, rheumatologists, dermatologists, pediatricians and neuro-pediatricians, physiotherapists and social workers. The center is managed by Director Professor Dr. med. Helmut Feistner, Spokesperson Prof. Dr. med. Stefan Vielhaber and Deputy Director Professor Dr. med. Ch. Marwin. In 2008 it became one of first German centers to be certified with a seal of quality by the German Society for Muscular Dystrophy.

The Department of Neurology of the Magdeburg University Hospital treats over 1,000 inpatients and outpatients with neuromuscular diseases annually. The Department has its own metabolic laboratory and imaging center (MRI, sonography). Together with the Institute of Neuropathology (Director: Prof. Dr. Ch. Mawrin) it evaluates more than 100 tissue samples per year (muscle, nerve, skin), as well as several hundred genetic samples analyzed by the Institute of Human Genetics (Prof. Dr. M. Zenker). Research on muscles diseases is conducted at the Magdeburg Muscle Center in the context of a close and long-standing cooperation with other national and international muscle centers. In addition, the Muscle center holds regular case conferences and provides continuing education for doctors and therapists as well as patients and their families.
In 2014 the Magdeburg Muscle Center joined the Central German Competence Network for Rare Diseases (MKSE) at the Magdeburg University Hospital, which is coordinated by Prof. Mohnike of the Children’s Hospital. The objective of the MKSE is the strengthening of interdisciplinary cooperation in the area of rare diseases. It organizes monthly case conferences and allows doctors to forward patient inquiries so that patients with suspected neuromuscular diseases are directed to the outpatient clinic.

Interdisciplinary Case Conferences

Regular case presentation with group discussions of individual medical histories and findings, as well as planning of patient-specific treatments, are conducted with participating specialist hospitals.

Special Patient Services

Physiotherapy, social care and aids counseling, psychological support, specialist advice and support for people with muscular disorders and their families, public relations.

Local support groups and discussion groups

The DGM In Saxony-Anhalt runs local support and discussion groups for Muscular Dystrophy patients and their families.
Contact information is available at www.sachsen-anhalt.dgm.org

 

Main focusses of The Magdeburg Muscle Center are the care for patients with Amyotrophic Lateral Sclerosis (with scientific studies being conducted in conjunction with Prof. Drs. R. Dengler and S. Petri of the Hannover Medical School). Special ambulances for patients with post-polio syndrome patients and patients with inflammatory muscle diseases and peripheral neuro-immunological disorders (e.g., as myasthenia gravis, chronic inflammatory neuropathies) are held. Nevertheless patients with all kinds of neuromuscular diseases are cared for in the centre.

Sponsorship of Research

The Christa Lorenz ALS Research Award
The "Christa Lorenz ALS Research Award" is given for outstanding original scientific papers on amyotrophic lateral sclerosis (ALS). The award, which provides an endowment of 15,000 Euros, was presented the first time by the Frankfurt am Main based Foundation for Medical Science on September 5, 2009 at the Magdeburg Faculty of Medicine. The initial recipient was scientist and clinician at the Ludwig Maximilian University in Munich, Dr. med. Stefan Lorenzl. In 2010 the award was given to Prof. Dr. Manuela Claudia Neumann, who works as an Assistant Professor of Experimental Neuropathology and Senior Physician at the Institute of Neuropathology at the University Hospital Zurich. In 2011 Professor Dr. Michael T. Heneka from the University Hospital of Bonn received the award for his outstanding scientific papers on ALS. In 2013 the award went Professor Dr. med. Susanne Petri of the Hannover Medical School (MHH) for her work on the use of stem cells to treat neuromuscular diseases, with ALS serving as a representative case. (more information)

The Frankfurt am Main Foundation for Medical Sciences was founded in 1999 by Christa Lorenz, who was herself afflicted with ALS and ultimately died from it. The Foundation’s purpose is to promote scientific research on this neurodegenerative disorder, which is regarded a model for other age-related neurological illnesses, such as dementia, that involve selective cell death.

» Adresses and Office Hours at the Magdeburg Muscle Center and Department of Neurology Director for the Muscle Center:
Prof. Dr. med. Helmut Feistner, Senior clinic physician and head of the EMG laboratories
Spokesperson:
Prof. Dr. med. Stefan Vielhaber, Deputy Director, Head of the Muscle Center of the metabolic laboratories

Otto von Guericke University Hospital
Department of Neurology, Leipziger Str. 44 (House 60B)
39120 Magdeburg, Germany
Phone.: +49(0)391-67-15031 (Poliklinik), -13484 (MVZ)
Fax: 0391-67-21684
E-mail: stefan.vielhaber@med.ovgu.de

ALS and other Motor Neurological Disorders (Outpatient clinic)
Prof. Dr. Vielhaber and Staff
Monday through Friday
Phone: +49(0)391-67-15001 (outpatient clinic),
Fax: 0391-67-21684

Public muscle consultation hours and EMG examinations
Prof. Dr. Vielhaber, Prof. Feistner, Fr. Dr. Stephanik, Fr. Dr. Bock /MVZ
Monday and Tuesday, by appointment
Phone: +49(0)391-67-13484 (MVZ), -15031 (outpatient clinic), -15022 (EMG)

Pediatric Muscle consultation hours and Myosonographie (In cooperation with the Children's Hospital and the Radiological Center)
Prof. Dr. Vielhaber, Prof. Dr. Mohnike, PD Dr. von Rohden, Prof. Feistner
by appointment
Phone: +49(0)391-67-15001 (Prof. Vielhaber)

Myasthenia consultation hours and chronic fatigue syndrome
Frau Dr. Bock, medical specialist
Phone: +49(0)391-67-13484 (MVZ)

Muscle MRI, proton MR spectroscopy, energy metabolism studies
Prof. Dr. Vielhaber, PD Dr. Gellerich
Phone: +49(0)391-67-15001 (Coordination: Prof. Dr. Vielhaber)

Orthopedic Medical Management
Phone: +49(0)391-67-14050 (Department of Orthopedics)

Molecular Genetic Laboratory, Institute of Human Genetics
Prof. Zenker, Dr. S. Jakubiczka
Phone: 0391-67-15343, 67-15063

Genetic counseling center, Institute of Human Genetics
Prof. Zenker, Frau Dr. P. Muschke
Phone: +49(0)391 - 67-17230

Hospital Social Services
Frau Hollstein
Phone: +49(0)391-67-15746

Nutritional Counseling
Appointment should be made through the clinic Secretary: Phone: +49(0)391-67-15001

  » Magdeburg Muscle Center and Associated Hospital Departments

  • Neurological Clinic and Clinical Neurophysiology at the Magdeburg University Hospital
    (Prof. Dr. med. H. J. Heinze, Prof. Dr. med. H. Feistner, Prof. Dr. med. S. Vielhaber),
  • Children’s Hospital (Prof. Dr. med. G. Jorch, Prof. Dr. med. K. Mohnike),
  • Orthopedics (Prof. Dr. med. Ch. Lohmann, PD Dr. med. A. Berth),
  • Human Genetics (Prof. Dr. med. M. Zenker, Frau Dr. med. S. Jakubiczka, Frau PD Dr. I. Wieland, Frau Dr. med. P. Muschke),
  • Pediatric Radiology (Prof. Dr. med. J. Ricke, Frau PD Dr. K. Fischbach, Frau Dr. med. G. Neumann, PD Dr. med. L. von Rohden),
  • Rheumatology (Prof. Dr. med. J. Kekow),
  • Dermatology (Prof. Dr. med. H. Gollnick, PD Dr. med. A. Ambach, Dr. med. M. Bellutti),
  • Neuropathology (Prof. Dr. med. Ch. Mawrin),
  • Cardiology (Prof. Dr. med. R. Braun-Dullaeus, Dr. I. Tanev),
  • Pulmonology (Prof. Dr. med. J. Schreiber, Dr. med. S. Föllner),
  • Social and Medical Counseling (Frau K. Hollstein),
  • Physiotherapy (Frau J. Ruby)
  • Nutritional counseling and medical aid supply (Fa. Strehlow GmbH; Coordination H. Bluhm)

 

Links

Department of Neurology Homepage
The German Society for Muscular Dystrophy e.V. (DGM)
Regional Association of the DGM
Centre for medical aid supply
Scientific Information
Neurology Events
Christa-Lorenz-ALS-Research Prize/Research Award

Selected Publications

Stoppel CM, Vielhaber S, Eckart C, Machts J, Kaufmann J, Heinze HJ, Kollewe K, Petri S, Dengler R, Hopf JM, Schoenfeld MA. Structural and functional hallmarks of amyotrophic lateral sclerosis progression in motor- and memory-related brain regions. Neuroimage Clin. 2014 Jul 22;5:277-90. doi: 10.1016/j.nicl.2014.07.007. eCollection 2014. PMID: 25161894 [PubMed - in process] Free PMC Article Related citations Select item 251550202.

Schreiber S, Abdulla S, Debska-Vielhaber G, Machts J, Dannhardt-Stieger V, Feistner H, Oldag A, Goertler M, Petri S, Kollewe K, Kropf S, Schreiber F, Heinze HJ, Dengler R, Nestor PJ, Vielhaber S. Peripheral nerve ultrasound in ALS phenotypes. Muscle Nerve. 2014 Aug 25. doi: 10.1002/mus.24431. [Epub ahead of print] PMID: 25155020 [PubMed - as supplied by publisher] Related citations Select item 250593913.

Cardenas-Blanco A, Machts J, Acosta-Cabronero J, Kaufmann J, Abdulla S, Kollewe K, Petri S, Heinze HJ, Dengler R, Vielhaber S, Nestor PJ. Central white matter degeneration in bulbar- and limb-onset amyotrophic lateral sclerosis. J Neurol. 2014 Jul 25. [Epub ahead of print] PMID: 25059391 [PubMed - as supplied by publisher] Related citations Select item 250229384.

Schuster C, Kasper E, Machts J, Bittner D, Kaufmann J, Benecke R, Teipel S, Vielhaber S, Prudlo J. Longitudinal course of cortical thickness decline in amyotrophic lateral sclerosis. J Neurol. 2014 Jul 15. [Epub ahead of print] PMID: 25022938 [PubMed - as supplied by publisher] Related citations Select item 250089795.

Abdulla S, Vielhaber S, Kollewe K, Machts J, Heinze HJ, Dengler R, Petri S. The impact of physical impairment on emotional well-being in ALS. Amyotroph Lateral Scler Frontotemporal Degener. 2014 Sep;15(5-6):392-7. doi: 10.3109/21678421.2014.932380. Epub 2014 Jul 10. PMID: 25008979 [PubMed - in process] Related citations Select item 250078296.

Abdulla S, Vielhaber S, Machts J, Heinze HJ, Dengler R, Petri S. Information needs and information-seeking preferences of ALS patients and their carers. Amyotroph Lateral Scler Frontotemporal Degener. 2014 Jul 10:1-8. [Epub ahead of print] PMID: 25007829 [PubMed - as supplied by publisher] Related citations Select item 250048917.

Abdulla S, Machts J, Kaufmann J, Patrick K, Kollewe K, Dengler R, Heinze HJ, Petri S, Vielhaber S, Nestor PJ. Hippocampal degeneration in patients with amyotrophic lateral sclerosis. Neurobiol Aging. 2014 Jun 11. pii: S0197-4580(14)00401-1. doi: 10.1016/j.neurobiolaging.2014.05.035. [Epub ahead of print] PMID: 25004891 [PubMed - as supplied by publisher] Related citations Select item 249818728.

Machts J, Bittner V, Kasper E, Schuster C, Prudlo J, Abdulla S, Kollewe K, Petri S, Dengler R, Heinze HJ, Vielhaber S, Schoenfeld MA, Bittner DM. Memory deficits in amyotrophic lateral sclerosis are not exclusively caused by executive dysfunction: a comparative neuropsychological study of amnestic mild cognitive impairment. BMC Neurosci. 2014 Jun 30;15:83. doi: 10.1186/1471-2202-15-83. PMID: 24981872 [PubMed - indexed for MEDLINE] Free PMC Article Related citations Select item 248255689.

Schreiber S, Drukarch B, Garz C, Niklass S, Stanaszek L, Kropf S, Bueche C, Held F, Vielhaber S, Attems J, Reymann KG, Heinze HJ, Carare RO, Wilhelmus MM. Interplay Between Age, Cerebral Small Vessel Disease, Parenchymal Amyloid-β, and Tau Pathology: Longitudinal Studies in Hypertensive Stroke-Prone Rats. J Alzheimers Dis. 2014 Jan 1;42(0):S205-15. doi: 10.3233/JAD-132618. PMID: 24825568 [PubMed - in process] Related citations Select item 2462704510.

Hübers A, Marroquin N, Schmoll B, Vielhaber S, Just M, Mayer B, Högel J, Dorst J, Mertens T, Just W, Aulitzky A, Wais V, Ludolpf AC, Kubisch C, Weishaupt JH, Volk AE. Polymerase chain reaction and southern blot-based analysis of the C9orf72 hexanucleotide repeat in different motor neuron diseases. Neurobiology of Aging 2014; 35: 1214.e1-1214.e6 IF: 6,166

 

Schuster C, Kasper E, Dybra E, Machts J, Bittner D, Kaufmann J, Mitchell AJ, Benecke R, Teipel S, Vielhaber S, Prudlo J. Cortical thinning and ITS relation to cognition in amyotrophic lateral sclerosis. Neurobiology of Aging 2014; 35: 240-246 IF: 6,166

Kupsch A, Schmidt W, Gizatullina Z, Debska-Vielhaber G, Voges J, Striggow F, Panther P, Schwegler H, Heinze HJ, Vielhaber S, Gellerich FN. 6-Hydroxydopamine impairs mitochondrial function in the rat model of Parkinson's disease: respirometric, histological, and behavioral analyses. J Neural Transm. 2014 Mar 14. [Epub ahead of print]

Boelmans K, Kaufmann J, Schmelzer S, Vielhaber S, Kornhuber M, Münchau A, Zierz S, Gaul C. Hirayama disease is a pure spinal motor neuron disorder: a combined DTI and transcranial magnetic stimulation study. In: Journal of neurology. - Heidelberg: Springer-Medizin-Verl, Bd. 260.2013, 2, S. 540-548; [Imp.fact.: 3,578]

Paege I, Vielhaber S, Petri S, Keilhoff G, Mawrin Ch. Dysregulation of iron protein expression in the G93A model of amyotrophic lateral sclerosis. In: Neuroscience. - Oxford: Elsevier, Bd. 230.2013, S. 94-101; [Imp.fact.: 3,122]

Schuster Ch, Kasper E, Machts J, Bittner D, Kaufmann J, Benecke R, Teipel S, Vielhaber S, Prudlo J. Focal thinning of the motor cortex mirrors clinical features of amyotrophic lateral sclerosis and their phenotypes: a neuroimaging study. In: Journal of neurology. - [Darmstadt]: Steinkopff, Bd. 260.2013, 11, S. 2856-2864; [Imp.fact.: 3,578]

Trumbeckaite S, Gizatullina Z, Arandarcikaite O, Röhnert P, Vielhaber S, Malesevic M, Fischer G, Seppet E, Striggow F, Gellerich FN. Oxygen glucose deprivation causes mitochondrial dysfunction in cultivated rat hippocampal slices: Protective effects of CsA, its immunosuppressive congener [D-Ser](8)CsA, the novel non-immunosuppressive cyclosporin derivative Cs9, and the NMDA receptor antagonist. MK 801. Mitochondrion. 2012.

Vielhaber S, Debska-Vielhaber G, Peeva V, Schoeler S, Kudin AP, Minin I, Schreiber S, Dengler R, Kollewe K, Zuschratter W, Kornblum C, Zsurka G, Kunz WS. Mitofusin 2 mutations affect mitochondrial function by mitochondrial DNA depletion. Acta Neuropathol. 2012. 22926664.

Regnery C, Kornblum C, Hanisch F, Vielhaber S, Strigl-Pill N, Grunert B, Müller-Felber W, Glocker FX, Spranger M, Deschauer M, Mengel E, Schoser B. 36 months observational clinical study of 38 adult Pompe disease patients under alglucosidase alfa enzyme replacement therapy.
J. Inherit. Metab. 35(5):837-45. 2012

Gellerich FN, Gizatullina Z, Trumbeckaite S, Korzeniewski B, Gaynutdinov T, Seppet E, Vielhaber S, Heinze HJ, Striggow F. Cytosolic Ca2+ regulates the energisation of isolated brain mitochondria by formation of pyruvate through the malate-aspartate shuttle. Biochem J. 443(3):747-55.2012

Hammer, A., Vielhaber, S., Rodriguez-Fornells, A., Mohammadi, B., Münte, T.F. (2011)
A neurophysiological analysis of working memory in amyotrophic lateral sclerosis.
Brain Res. 1421:90-9.

Vielhaber, S., Brejova, A., Debska-Vielhaber, G., Kaufmann, J., Feistner, H., Schoenfeld, A.M. & Awiszus, F. (2011)
24-months results in adults with Pompe disease on enzyme replacement therapy.
Clin. Neurol. Neurosurg., 113:350-357.

Niehusmann, P., Surges, R., von Wrede, R.D., Elger, C.E., Wellmer, J., Reimann, J., Urbach, H., Vielhaber, S., Bien, C.G. & Kunz, W.S. (2011)
Mitochondrial dysfunction due to Leber's hereditary optic neuropathy as a cause of visual loss during assessment for epilepsy surgery.
Epilepsy Behav. 20:38-43.

Gizatullina, Z., Gaynutdinov, T. M., Svoboda, H., Jerzembek, D., Knabe, A., Vielhaber, S., Malesevic, M., Heinze, H.J., Fischer, G., Striggow, F. & Gellerich, F. N. (2011)
Effects of cyclosporine A and its immunosuppressive or non-immunosuppressive derivatives [D-Ser]8-CsA and Cs9 on mitochondria from different brain regions.
Mitochondrion 11:421-429.

Gellerich, F.N., Gizatullina, Z., Trumbeckaite, S., Arandacikaite, O., Vielhaber, S., Seppet, E. & Striggow., F. (2010)
The regulation of OXPHOS by extramitochondrial calcium.
Biochim. Biophys. Acta 1797:1018-27.

Gellerich, F. N., Gizatullina, Z., Arandacikaite, O., Jerzembeck, D., Vielhaber, S., Seppet, E. & Striggow, F. (2010)
Extramitochondrial Ca2+ in the nanomolar range regulates glutamate-dependent oxidative phosphorylation on demand.
PLOS 4:e8181

Winter, Y., Schepelmann, K., Spottke, A.E., Claus, D., Grothe, C., Schröder, R., Heuss, D., Vielhaber, S., Tackenberg, B., Mylius, V., Reese, J. P., Kiefer, R., Schrank, B., Oertel, W. H. & Dodel R. (2010)
Health-related quality of life in ALS, myasthenia gravis and facioscapulohumeral muscular dystrophy.
J. Neurol. 257:1473-1481.

Strothotte S, Strigl-Pill N, Grunert B, Kornblum C, Eger K, Wessig C, Deschauer M, Breunig F, Glocker FX, Vielhaber S, Brejova A, Hilz M, Reiners K, Müller-Felber W, Mengel E, Spranger M, Schoser B.
Enzyme replacement therapy with alglucosidase alfa in 44 patients with late-onset glycogen storage disease type 2: 12-month results of an observational clinical trial. J Neurol 2010; 257:91-97 IF: 2.903

Winter Y, Schepelmann K, Spottke AE, Claus D, Grothe C, Schröder R, Heuss D, Vielhaber S, Tackenberg B, Mylius V, Reese JP, Kiefer , Schrank B, Oertel WH, Dodel R. Health-related quality of life in ALS, myasthenia gravis and facioscapulohumeral muscular dystrophy. J Neurol 2010; 257:1473-1481 IF: 2.90

Boelmans K, Fischbach F, Mirastschijsk, U, Vielhaber S: Bilateral idiopathic hypertrophy of the fi rst dorsal interosseous muscles in a 43-yearold man. J Neuro Neurosurg Psychiatry 2008, 79:996.

Reichlich P, Petersen JA, Vielhaber S, Mawrin C, Schneider-Gold C, Sommer C, Reiners K, Deschauer M, Pongratz D, Lochmüller H, Walter MC: LGMD 2I due to the common mutation 826C>A in the FKRP gene presentingas myopathy with vacuoles and paired-helical filaments. Act a Myologica 2007, XXV:73-76.

Semmler A, Kress W, Vielhaber S, Schade G, Schroeder R, Klockgether T, Kornblum C: Variability of the recessive oculopharyngeal muscular dystrophy phenotype. Muscle Nerve 2007, 35:681-684.

Schulz S, Vielhaber S, Muschke P, Mohnicke K, Gooding R, Wieacker P: Congenital cataract , ataxia, external ophthalmoplegia, and dysphagia in two German siblings. A Marinesco-Sjögren-like syndrome without mutation in SIL1. Neuropediatrics 2007, 38:88-90.

Vielhaber S, Jakubiczka S, Gaul C, Schoenfeld MA, Debska-Vielhaber G, Zierz S, Heinze HJ, Niessen HG, Kaufmann J: Brain 1H magnetic resonance spect roscopic differences in myotonic dystrophy type 2 and type 1. Muscle Nerve 2006, 34:145-152.

 

 

 

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