Otto-von-Guericke-Universität Magdeburg

University Department of Neurology

Mixed cerebral pathologies and cognitive aging



PD Dr. med. Stefanie Schreiber
senior physician neurology

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Cornelia Garz

Head and project coordination
Cornelia Garz, technician

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Methodological spectrum of 2-photon imaging 
Solveig Niklass, MSc biosystems technology
PhD student

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Friederike Held

Perivascular Aβ-drainage mechanisms and transmission electron microscopy
Friederike Held
MD student

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Untersuchungen des endothelialen Transkriptoms an der SHRSP
Naomie Lämmlin
MD student

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Daniel Schwanke102

Temporal cascade of age-dependent mixed cerebral pathologies in SHRSP and in human brains
Daniel Schwanke
MD student

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Retinal biomarkers to predict the mixed pathologies of the aging brain
Maximilian Scheifele
MD student

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Mike Baur102x146

Longitudinale Studien am Modell der spontan-hypertensiven stroke prone Ratte (SHRSP)
Mike Baur
MD student

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Luiza Stanaszek Matrix metalloproteinases and extracellular matrix
Luiza Stanaszek, MSc, PhD

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Celine Büche Pharmacological modifications of mixed cerebral pathologies
Dr. rer. nat. Celine Zoe Büche

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Anni Schulze102 Anni Schulze
MD studentsend Email
Annette Wilisch-Neumann102x146 Project coordination, cerebral small vessel disease and neurodegeneration
Dr. rer. nat. Annette Wilisch-Neuman
Biologist/Molecular biologist



Mixed cerebral pathologies including cerebral small vessel disease (CSVD), amyloid β (Aβ) deposits and neurodegeneration are common features of the aging brain. In their sum they are presumed to accelerate cognitive aging and dementia development. The causal interplay between those mixed pathologies has been barely investigated so far. Indeed, the development of progressive prevention and therapeutic strategies against cognitive aging and dementia provides the detailed understanding of the interaction between all those neuropathological players.

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Schreiber S, Landau SM, Fero A, Schreiber F, Jagust WJ. Comparison of Visual and Quantitative Florbetapir F18 Positron Emission Tomography Analysis in Predicting Mild Cognitive Impairment Outcomes. JAMA Neurology. in press

Bueche CZ, Garz C, Stanaszek L, Niklass S, Kropf S, Bittner D, Härtig W, Reymann KG, Heinze HJ, Carare RO, Schreiber S. Impact of N-Acetylcysteine on Cerebral Amyloid-β Plaques and Kidney Damage in Spontaneously Hypertensive Stroke-Prone Rats. J Alzheimers Dis. 2014;42 Suppl 3:S305-13.

Schreiber S, Drukarch B, Garz C, Niklass S, Stanaszek L, Kropf S, Bueche C, Held F, Vielhaber S, Attems J, Reymann KG, Heinze HJ, Carare RO, Wilhelmus MM. Interplay Between Age, Cerebral Small Vessel Disease, Parenchymal Amyloid-β, and Tau Pathology: Longitudinal Studies in Hypertensive Stroke-Prone Rats. J Alzheimers Dis. 2014;42 Suppl 3:S205-15.

Niklass S, Stoyanov S, Garz C, Bueche CZ, Mencl S, Reymann K, Heinze HJ, Carare RO, Kleinschnitz C, Schreiber S. Intravital imaging in spontaneously hypertensive stroke-prone rats-a pilot study. Exp Transl Stroke Med. 2014 Jan 25;6(1):1.

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Last Modification: 30.03.2017 - Contact Person: Ögelin Düzel

  » CANLAB - Clinical Affective
Neuroimaging Laboratory

Demenz und kognitive Störung
  » Dementia/Cognitive

Memory and Consciousness
  » Memory and Consciousness

  » Magnetic Resonance Imaging

  » MEG

  » Neuropsychology

Restaurative Neurologie
  » Restaurative Neurology

Mischpathologien des zerebralen Alterns
  » Mixed cerebral pathologies
and cognitive aging

Brain Machine Interface
  » Brain Machine Interface