UNIVERSITÄTSKLINIK FÜR NEUROLOGIE

 

Kasper E, Temp AGM, Köckritz V, Meier L, Machts J, Vielhaber S, Hermann A, Prudlo J. Verbal expressive language minimally affected in non-demented people living with amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener. 2024, 25(3-4):308-316. doi: 10.1080/21678421.2024.2307512. Epub 2024 Feb 2.

Arndt P, Chahem C, Luchtmann M, Kuschel JN, Behme D, Pfister M, Neumann J, Görtler M, Dörner M, Pawlitzki M, Jansen R, Meuth SG, Vielhaber S, Henneicke S, Schreiber S. Risk factors for intracerebral hemorrhage in small-vessel disease and non-small-vessel disease etiologies-an observational proof-of-concept study. Front Neurol. 2024 15:1322442. doi: 10.3389/fneur.2024.1322442. eCollection 2024.

Northall A, Doehler J, Weber M, Tellez I, Petri S, Prudlo J, Vielhaber S, Schreiber S, Kuehn E. Multimodal layer modelling reveals in vivo pathology in amyotrophic lateral sclerosis. Brain. 2024 Mar 1;147(3):1087-1099. doi: 10.1093/brain/awad351.

 

Räuber S, Nelke C, Schroeter CB, Barman S, Pawlitzki M, Ingwersen J, Akgün K, Günther R, Garza AP, Marggraf M, Dunay IR, Schreiber S, Vielhaber S, Ziemssen T, Melzer N, Ruck T, Meuth SG, Herty M. Classifying flow cytometry data using Bayesian analysis helps to distinguish ALS patients from healthy controls. Front Immunol. 2023, 14:1198860. doi: 10.3389/fimmu.2023.1198860. eCollection 2023.

Northall A, Doehler J, Weber M, Vielhaber S, Schreiber S, Kuehn E. Layer-specific vulnerability is a mechanism of topographic map aging. Neurobiol Aging. 2023, 128:17-32. doi: 10.1016/j.neurobiolaging.2023.04.002. Epub 2023 Apr 6.

Vogt S, Pfau G, Vielhaber S, Haghikia A, Hachenberg T, Brinkers M, Long-term opioid therapy and mental health comorbidity in patients with chronic pain.  Pain Med. 2023, 24(7):837-845. doi: 10.1093/pm/pnad004.

Hildebrand A, Schreiber F, Weber L, Arndt P, Garz C, Petri S, Prudlo J, Meuth SG, Waerzeggers Y, Henneicke S, Vielhaber S, Schreiber S. Peripheral Nerve Ultrasound for the Differentiation between ALS, Inflammatory, and Hereditary Polyneuropathies. Medicina (Kaunas). 2023, 59(7):1192. doi: 10.3390/medicina59071192.

Schreiber S, Bernal J, Arndt P, Schreiber F, Müller P, Morton L, Braun-Dullaeus RC, Valdés-Hernández MDC, Duarte R, Wardlaw JM, Meuth SG, Mietzner G, Vielhaber S, Dunay IR, Dityatev A, Jandke S, Mattern H. Brain Vascular Health in ALS Is Mediated through Motor Cortex Microvascular Integrity. Cells. 2023, 12(6):957. doi: 10.3390/cells12060957.

Gainutdinov T, Gizatullina Z, Debska-Vielhaber G, Vielhaber S, Feldmann RE Jr, Orynbayeva Z, Gellerich FN. Corrigendum to "Age-associated alterations of brain mitochondria energetics" [Biochem. Biophys. Res. Commun. 643 (2023) 1-7]Biochem Biophys Res Commun. 2023, 644:171. doi: 10.1016/j.bbrc.2023.01.015. Epub 2023 Jan 14.

Gainutdinov T, Gizatullina Z, Debska-Vielhaber G, Vielhaber S, Feldmann RE, Orynbayeva Z, Gellerich FN. Age-associated alterations of brain mitochondria energetics. Biochem Biophys Res Commun. 2023, 643:1-7. doi: 10.1016/j.bbrc.2022.12.070. Epub 2022 Dec 23.

 

Hermann A, Tarakdjian GN, Temp AGM, Kasper E, Machts J, Kaufmann J, Vielhaber S, Prudlo J, Cole JH, Teipel S, Dyrba M. Cognitive and behavioural but not motor impairment increases brain age in amyotrophic lateral sclerosis. Brain Commun. 2022, 4(5):fcac239. doi: 10.1093/braincomms/fcac239. eCollection 2022.

Temp AGM, Kasper E, Machts J, Vielhaber S, Teipel S, Hermann A, Prudlo J. Cognitive reserve protects ALS-typical cognitive domains: A longitudinal study. Ann Clin Transl Neurol. 2022, 9(8):1212-1223. doi: 10.1002/acn3.51623. Epub 2022 Jul 22.

Nelke C, Schroeter CB, Stascheit F, Pawlitzki M, Regner-Nelke L, Huntemann N, Arat E, Öztürk M, Melzer N, Mergenthaler P, Gassa A, Stetefeld H, Schroeter M, Berger B, Totzeck A, Hagenacker T, Schreiber S, Vielhaber S, Hartung HP, Meisel A, Wiendl H, Meuth SG, Ruck T. Eculizumab versus rituximab in generalised myasthenia gravis. J Neurol Neurosurg Psychiatry. 2022, 93(5):548-554. doi: 10.1136/jnnp-2021-328665. Epub 2022 Mar 

Wigand B, Schlichte I, Schreiber S, Heitmann J, Meyer T, Dengler R, Petri S, Haghikia A, Vielhaber S, Vogt S. Characteristics of pain and the burden it causes in patients with amyotrophic lateral sclerosis - a longitudinal study. Amyotroph Lateral Scler Frontotemporal Degener. 2022, 23(3-4):284-291. doi: 10.1080/21678421.2021.1962354. Epub 2021 Aug 14.

Enax-Krumova EK, Dahlhaus I, Görlach J, Claeys KG, Montagnese F, Schneider L, Sturm D, Fangerau T, Schlierbach H, Roth A, Wanschitz JV, Löscher WN, Güttsches AK, Vielhaber S, Hasseli R, Zunk L, Krämer HH, Hahn A, Schoser B, Rosenbohm A, Schänzer A. Small fiber involvement is independent from clinical pain in late-onset Pompe disease.

Orphanet J Rare Dis. 2022, 17(1):177. doi: 10.1186/s13023-022-02327-4.

Nelke C, Stascheit F, Eckert C, Pawlitzki M, Schroeter CB, Huntemann N, Mergenthaler P, Arat E, Öztürk M, Foell D, Schreiber S, Vielhaber S, Gassa A, Stetefeld H, Schroeter M, Berger B, Totzeck A, Hagenacker T, Meuth SG, Meisel A, Wiendl H, Ruck T. Independent risk factors for myasthenic crisis and disease exacerbation in a retrospective cohort of myasthenia gravis patients. J Neuroinflammation. 2022, 19(1):89. doi: 10.1186/s12974-022-02448-4.

Hußler W, Höhn L, Stolz C, Vielhaber S, Garz C, Schmitt FC, Gundelfinger ED, Schreiber S, Seidenbecher CI. Brevican and Neurocan Cleavage Products in the Cerebrospinal Fluid - Differential Occurrence in ALS, Epilepsy and Small Vessel Disease.

Front Cell Neurosci. 2022,16:838432. doi: 10.3389/fncel.2022.838432. eCollection 2022.

 

Vogt S, Schlichte I, Schreiber S, Wigand B, Debska-Vielhaber G, Heitmann J, Meyer T, Dengler R, Petri S, Haghikia A, Vielhaber S. A Multi-Center Cohort Study on Characteristics of Pain, Its Impact and Pharmacotherapeutic Management in Patients with ALS. J Clin Med. 2021 Sep 30;10(19):4552. doi: 10.3390/jcm10194552.

Kobeleva X, Machts J, Veit M, Vielhaber S, Petri S, Schoenfeld MA. Brain activity is contingent on neuropsychological function in a functional magnetic resonance imaging study of verbal working memory in amyotrophic lateral sclerosis. Eur J Neurol. 2021, 28(9):3051-3060. doi: 10.1111/ene.14957. Epub 2021 Jun 29.

Rolfes L, Schulte-Mecklenbeck A, Schreiber S, Vielhaber S, Herty M, Marten A, Pfeuffer S, Ruck T, Wiendl H, Gross CC, Meuth SG, Boentert M, Pawlitzki M. 
Amyotrophic lateral sclerosis patients show increased peripheral and intrathecal T-cell activation. Brain Commun. 2021, 3(3):fcab157. doi: 10.1093/braincomms/fcab157. eCollection 2021.

Temp AGM, Dyrba M, Büttner C, Kasper E, Machts J, Kaufmann J, Vielhaber S, Teipel S, Prudlo J. Cognitive Profiles of Amyotrophic Lateral Sclerosis Differ in Resting-State Functional Connectivity: An fMRI Study. Front Neurosci. 2021, 15:682100. doi: 10.3389/fnins.2021.682100. eCollection 2021.

Drabik K, Malińska D, Piecyk K, Dębska-Vielhaber G, Vielhaber S, Duszyński J, Szczepanowska J. Effect of Chronic Stress Present in Fibroblasts Derived from Patients with a Sporadic Form of AD on Mitochondrial Function and Mitochondrial Turnover. Antioxidants (Basel). 2021, 10(6):938. doi: 10.3390/antiox10060938.

Drabik K, Piecyk K, Wolny A, Szulc-Dąbrowska L, Dębska-Vielhaber G, Vielhaber S, Duszyński J, Malińska D, Szczepanowska J. Adaptation of mitochondrial network dynamics and velocity of mitochondrial movement to chronic stress present in fibroblasts derived from patients with sporadic form of Alzheimer's disease. FASEB J. 2021,35(6):e21586. doi: 10.1096/fj.202001978RR.

Temp AGM, Prudlo J, Vielhaber S, Machts J, Hermann A, Teipel SJ, Kasper E. Cognitive reserve and regional brain volume in amyotrophic lateral sclerosis. 
Cortex. 2021, 139:240-248. doi: 10.1016/j.cortex.2021.03.005. Epub 2021 Mar 17.

Debska-Vielhaber G, Miller I, Peeva V, Zuschratter W, Walczak J, Schreiber S, Petri S, Machts J, Vogt S, Szczepanowska J, Gellerich FN, Hermann A, Vielhaber S, Kunz WS. 
Impairment of mitochondrial oxidative phosphorylation in skin fibroblasts of SALS and FALS patients is rescued by in vitro treatment with ROS scavengers. 
Exp Neurol. 2021, 339:113620. doi: 10.1016/j.expneurol.2021.113620. Epub 2021 Jan 23.

Machts J, Keute M, Kaufmann J, Schreiber S, Kasper E, Petri S, Prudlo J, Vielhaber S, Schoenfeld MA. Longitudinal clinical and neuroanatomical correlates of memory impairment in motor neuron disease. Neuroimage Clin. 2021, 29:102545. doi:10.1016/j.nicl.2020.102545. Epub 2020 Dec 25.

Schreiber S, Northall A, Weber M, Vielhaber S, Kuehn E. Topographical layer imaging as a tool to track neurodegenerative disease spread in M1Nat Rev Neurosci. 2021, 22(1):68-69. doi: 10.1038/s41583-020-00404-w.

 

Dengler R, Carvalho M de, Shahrizaila N, Nodera H, Vucic S, Grimm A, Padua L, Schreiber S, Kneiser MK, Hobson-Webb LD, Boon AJ, Smith BE, Litchy WJ, Li Y, Lenihan M, Thompson VB, Stalberg E, Sanders DB, Kincaid JC. AANEM - IFCN glossary of terms in neuromuscular electrodiagnostic medicine and ultrasound. Clin Neurophysiol 2020; 131(7):1662–1663. doi: 10.1016/j.clinph.2020.03.014. Muscle & Nerve 2020; 62(1):10–12. doi:10.1002/mus.26868.

Dörner M, Schreiber F, Stephanik H, Tempelmann C, Winter N, Stahl J-H, Wittlinger J, Willikens S, Kramer M, Heinze H-J, Vielhaber S, Schelle T, Grimm A, Schreiber S. Peripheral Nerve Imaging Aids in the Diagnosis of Immune-Mediated Neuropathies–A Case Series. Diagnostics 2020; 10(8):535. doi:10.3390/diagnostics10080535.

Gellerich FN, Szibor M, Gizatullina Z, Lessmann V, Schwarzer M, Doenst T, Vielhaber S, Kunz WS. Reply to Rutter et al.: The roles of cytosolic and intramitochondrial Ca2+ and the mitochondrial Ca2+-uniporter (MCU) in the stimulation of mammalian oxidative phosphorylation. J Biol Chem. 2020; 295(30):10507. doi:10.1074/jbc.RL120.014342.

Hensiek N, Schreiber F, Wimmer T, Kaufmann J, Machts J, Fahlbusch L, Garz C, Vogt S, Prudlo J, Dengler R, Petri S, Nestor PJ, Vielhaber S, Schreiber S. Sonographic and 3T-MRI-based evaluation of the tongue in ALS. Neuroimage Clin 2020; 26:102233.  doi:10.1016/j.nicl.2020.102233.

Körtvelyessy P, Kuhle J, Düzel E, Vielhaber S, Schmidt C, Heinius A, Leypoldt F, Schraven B, Reinhold D, Leppert D, Goihl A. Ratio and index of Neurofilament light chain indicate its origin in Guillain-Barré Syndrome. Ann Clin Transl Neurol. 2020; 7(11):2213-2220. doi:10.1002/acn3.51207

Kulessa M, Weyer-Menkhoff I, Viergutz L, Kornblum C, Claeys KG, Schneider I, Plöckinger U, Young P, Boentert M, Vielhaber S, Mawrin C, Bergmann M, Weis J, Ziagaki A, Stenzel W, Deschauer M, Nolte D, Hahn A, Schoser B, Schänzer A. An integrative correlation of myopathology, phenotype, and genotype in late onset Pompe disease. Neuropathol Appl Neurobiol. 2020; 46(4):359-374. doi:10.1111/nan.12580. 

Luecke E, Ganzert C, Vielhaber S, Haybaeck J, Jechorek D, Mawrin C, Schreiber J. Immune Checkpoint Inhibitor-induced Fatal Myositis in a Patient With Squamous Cell Carcinoma and a History of Thymoma. Clin Lung Cancer. 2020; 21(4):e246-e249. doi:10.1016/j.cllc.2020.01.008.

Schreiber F, Garz C, Heinze H-J, Petri S, Vielhaber S, Schreiber S. Textural markers of ultrasonographic nerve alterations in ALS. Muscle Nerve 2020; (Online ahead of print). doi:10.1002/mus.27043.

Schreiber S, Northall A, Weber M, Vielhaber S, Kuehn E. Topographical layer imaging as a tool to track neurodegenerative disease spread in M1. Nat Rev Neurosci 2020; (Online ahead of print). doi:10.1038/s41583-020-00404-w.

 

Temp AGM, Tarakdjian GN, Kasper E, Machts J, Kaufmann J, Vielhaber S, Prudlo J, Cole JH, Dyrba M, Teipel S, Hermann A. The role of cognitive and brain reserve in the clinical presentation and progression of amyotrophic lateral sclerosis. Sci Rep. 2025 Jun 20;15(1):20232. doi: 10.1038/s41598-025-97509-y. PMID: 40542104; PMCID: PMC12181229. .

Tröger J, Rouvalis A, Dörr F, Schwed L, Linz N, König A, Machts J, Vielhaber S, Thies T, Prudlo J, Hermann A, Kasper E. Automatically measured speech intelligibility models bulbar-specific disease severity and progression in Amyotrophic Lateral Sclerosis. Amyotroph Lateral Scler Frontotemporal Degener. 2025 Aug 24:1-9. doi: 10.1080/21678421.2025.2549317. Epub ahead of print. PMID: 40851280.

Lehto A, Zapf A, Hermann A, Machts J, Vielhaber S, Koppenbrink J, Edbauer D, Kasper E, Prudlo J. Homozygosity for the C allele at UNC13A rs12608932 seems to compromise cognition in ALS independently of the cognitive domains. Amyotroph Lateral Scler Frontotemporal Degener. 2026 Jan 2:1-4. doi: 10.1080/21678421.2025.2608238. Epub ahead of print. PMID: 41481541.

Letzte Änderung: 14.01.2026 - Ansprechpartner:

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